Molecular biology in medicinal chemistry/
| Other Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Weinheim:
Wiley-VCH,
c2004
|
| Series: | Methods and principles in medicinal chemistry
21 |
| Subjects: |
Table of Contents:
- Part I. Molecular targets
- 1. Cellular assays in drug discovery
- 2. Gene knockout models
- 3. Reporter gene assay system for the investigation of G-protein-coupled receptors
- 4. From the human genome to new drugs: the potential of orphan G-protein-coupled receptors
- Part II. Synthesis
- 5. Stereoselective synthesis with the help of recombinant enzymes
- 6. Nucleic acid drugs
- Part III. Analysis
- 7. Recent trends in enantioseperation of chiral drugs
- 8. Affinity chromatography
- 9. Nucleic magnetic resonance-based drug discovery
- 10. C-and N-Isotopic labeling of proteins
- 11. Application of antibody fragments as crystallization enhancers
- Part IV. Kinetics, metabolism and toxicology
- 12. Pharmacogenetics: the effect of inherited genetic variation on drug disposition and drug response
- 13. Pharmacogenemics of biovailability and elimination
- 14. Toxicogenomics: integration of new molecular biological tools in toxicology
- Index