Cover Image

The oncogene and tumour suppressor gene factsbook /

Main Author: Hesketh, Robin.
Format: Book
Language:English
Published: San Diego, Calif. : Academic Press, ©1997.
Edition:2nd ed.
Series:Factsbook series
Subjects:
Oncogenes.
Antioncogenes.
Genes, Tumor Suppressor.
MEDICAL > Oncology.
HEALTH & FITNESS > Diseases > Cancer.
Oncogenen.
Suppressorgenen.
Table of Contents:
  • The Introductory Chapters:
  • Introduction: Identification of Oncogenes.
  • Oncogene Activation in Humans.
  • Proliferation Control Pathways: Oncoprotein Function.
  • Growth Factor-Related Proteins.
  • SRC. RAS and RAF.
  • Nuclear Oncoproteins.
  • ETS. FOS and JUN. MYB. MYC. REL. ERBA.
  • Tumour Suppressor Genes: RB1. P53.
  • Other Major Tumour Suppressor Genes.
  • APC. BRCA1. NF1. VHL. WT1.
  • Cell Cycle Control: Cyclin-Dependent Kinase Inhibitors (CDKIs).
  • Apoptosis: Tumour Suppressor Genes and Apoptosis.
  • DNA Repair.
  • Angiogenesis and Metastasis: Angiogenesis.
  • Angiogenic Promoters.
  • Angiogenic Inhibitors.
  • Metastasis: Correlations with Gene Expression.
  • Cadherins.
  • The Immunoglobulin Superfamily (IgSF), Neural Cell-Adhesion Molecule (NCAM).
  • Integrins.
  • CD44.
  • Matrix Metalloproteinases (MMPS).
  • Tissue Inhibitors of Metalloproteinases (TIMPs).
  • Cysteine and Aspartic Proteinases and Heparanase.
  • NME1 and NME2.
  • The Multi-step Nature of Cancer: Cervical Carcinoma.
  • Colorectal Carcinoma.
  • Breast Carcinoma.
  • Prostate Carcinoma.
  • Renal Cell Carcinoma.
  • Lung Carcinoma.
  • Lymphomas.
  • Chronic Myeloid Leukemia.
  • Gene Therapy for Cancer: Nucleotide Sequence-Targeted Strategies.
  • Tumour Suppressor Gene Therapy.
  • Cytokine Gene Therapy and Tumour Vaccination.
  • Virally Directed Enzyme Prodrug Therapy (VDEPT).
  • Antibody-directed Therapy.
  • Tables:
  • Oncogenes Transduced by Retroviruses.
  • Oncogenes Activated by Retroviral Insertion.
  • Oncogenes at Chromosomal Translocations.
  • Tumour Suppressor Genes Detected in Human Tumours.
  • Functions of Oncoproteins.
  • Chromosome Locations of Human Proto-Oncogenes and Tumour Suppressor Genes.
  • The Oncogenes:
  • ABL. AKT1 and AKT2. BCL2. BCL3. BCR. CBL. CDK4. CRK. CSFIR/FMS. D Cyclins. DBL. EGFR/ErbB. ELK1. EPH. ERG. ETS1 and ETS2. FGR. FLII. FOS. FOSB. FPS/FES. FRA1 and FRA2. FYN. HCK. HER2/ErbB-2/Neu. HER3/ErbB-3. HER4/ErbB-4. HSTF1/HST2. INT2. JUN. JUNB. JUND. KIT. LCK. LYN. MAS. MAX. MET. Mil. MOS. MYB. MYC. PDGF/Sis. PIM1. RAF. RAS. REL. RET. ROS1. SEA. SKI. SRC. TAL1. THRA/ErbA-1 and THRA2/ErbA-2. TIAM1. TRK. VAV. WNT1. WNT2 and WNT3. YES1.
  • Tumour Suppressor Genes:
  • APC and MCC. BRCA1 and BRCA2. DCC. DPC4. E2F1. E-cadherin/CDH1. MSH2. MSH3. MSH6/GTBP and MLHL. NF1 and NF2. P53, PTC.
  • The Retinoblastoma Gene (RB1). TGFBR1 and TGFBR2. VHL; WT1.
  • Cyclin-dependent Kinase Inhibitors:
  • INK4A/MTS1/MTS2/CDK41/CDKN2. INK4B/MTS2.
  • INK4C and INK4D. KIP1. KIP2. WAF1.
  • DNA Tumour Viruses:
  • Human Papillomaviruses.
  • Epstein-Barr Virus.
  • Subject Index.
  • Sect. 1. The introductory chapters
  • Genetic events in cancer delelopment
  • Proliferation control pathways
  • Tumour suppressor genes
  • Cell cycle control
  • Apoptosis
  • DNA repair
  • Angiogenesis and metastasis
  • The multistep nature of cancer
  • Gene therapy for cancer
  • Sect. 2. Tables
  • Oncogenes transduced by retroviruses
  • Oncogenes activated by retroviral insertion
  • Oncogenes at chromosomal translocations
  • Tumour suppressor genes detected in human tumours
  • Functions of oncoproteins
  • Chromosome locations of human proto-oncogenes and tumour
  • suppressor genes
  • Sect. 3. The oncogenes
  • Sect. 4. Tumour suppressor genes
  • Sect. 5. Cyclin-dependent kinase inhibitors
  • Sect. 6. DNA tumour viruses.

Similar Items