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04642nam a2200397 a 4500 |
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20171112000015.0 |
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070806s1997 caua ob 001 0 eng d |
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|a 9780123445483
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|a 0123445485
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|a 9780080538006
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|a 0080538002
|q (electronic bk.)
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|a OPELS
|b eng
|e pn
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|a RC268.42
|b .H47 1997eb
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|a Hesketh, Robin.
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|a The oncogene and tumour suppressor gene factsbook /
|c Robin Hesketh.
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| 250 |
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4 |
|a 2nd ed.
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| 260 |
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4 |
|a San Diego, Calif. :
|b Academic Press,
|c ©1997.
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| 300 |
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|a 1 online resource (xiv, 549 pages) :
|b illustrations.
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| 490 |
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|a Factsbook series
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|a Includes bibliographical references and index.
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|a The Introductory Chapters: -- Introduction: Identification of Oncogenes. -- Oncogene Activation in Humans. -- Proliferation Control Pathways: Oncoprotein Function. -- Growth Factor-Related Proteins. -- SRC. RAS and RAF. -- Nuclear Oncoproteins. -- ETS. FOS and JUN. MYB. MYC. REL. ERBA. -- Tumour Suppressor Genes: RB1. P53. -- Other Major Tumour Suppressor Genes. -- APC. BRCA1. NF1. VHL. WT1. -- Cell Cycle Control: Cyclin-Dependent Kinase Inhibitors (CDKIs). -- Apoptosis: Tumour Suppressor Genes and Apoptosis. -- DNA Repair. -- Angiogenesis and Metastasis: Angiogenesis. -- Angiogenic Promoters. -- Angiogenic Inhibitors. -- Metastasis: Correlations with Gene Expression. -- Cadherins. -- The Immunoglobulin Superfamily (IgSF), Neural Cell-Adhesion Molecule (NCAM). -- Integrins. -- CD44. -- Matrix Metalloproteinases (MMPS). -- Tissue Inhibitors of Metalloproteinases (TIMPs). -- Cysteine and Aspartic Proteinases and Heparanase. -- NME1 and NME2. -- The Multi-step Nature of Cancer: Cervical Carcinoma. -- Colorectal Carcinoma. -- Breast Carcinoma. -- Prostate Carcinoma. -- Renal Cell Carcinoma. -- Lung Carcinoma. -- Lymphomas. -- Chronic Myeloid Leukemia. -- Gene Therapy for Cancer: Nucleotide Sequence-Targeted Strategies. -- Tumour Suppressor Gene Therapy. -- Cytokine Gene Therapy and Tumour Vaccination. -- Virally Directed Enzyme Prodrug Therapy (VDEPT). -- Antibody-directed Therapy. -- Tables: -- Oncogenes Transduced by Retroviruses. -- Oncogenes Activated by Retroviral Insertion. -- Oncogenes at Chromosomal Translocations. -- Tumour Suppressor Genes Detected in Human Tumours. -- Functions of Oncoproteins. -- Chromosome Locations of Human Proto-Oncogenes and Tumour Suppressor Genes. -- The Oncogenes: -- ABL. AKT1 and AKT2. BCL2. BCL3. BCR. CBL. CDK4. CRK. CSFIR/FMS. D Cyclins. DBL. EGFR/ErbB. ELK1. EPH. ERG. ETS1 and ETS2. FGR. FLII. FOS. FOSB. FPS/FES. FRA1 and FRA2. FYN. HCK. HER2/ErbB-2/Neu. HER3/ErbB-3. HER4/ErbB-4. HSTF1/HST2. INT2. JUN. JUNB. JUND. KIT. LCK. LYN. MAS. MAX. MET. Mil. MOS. MYB. MYC. PDGF/Sis. PIM1. RAF. RAS. REL. RET. ROS1. SEA. SKI. SRC. TAL1. THRA/ErbA-1 and THRA2/ErbA-2. TIAM1. TRK. VAV. WNT1. WNT2 and WNT3. YES1. -- Tumour Suppressor Genes: -- APC and MCC. BRCA1 and BRCA2. DCC. DPC4. E2F1. E-cadherin/CDH1. MSH2. MSH3. MSH6/GTBP and MLHL. NF1 and NF2. P53, PTC. -- The Retinoblastoma Gene (RB1). TGFBR1 and TGFBR2. VHL; WT1. -- Cyclin-dependent Kinase Inhibitors: -- INK4A/MTS1/MTS2/CDK41/CDKN2. INK4B/MTS2. -- INK4C and INK4D. KIP1. KIP2. WAF1. -- DNA Tumour Viruses: -- Human Papillomaviruses. -- Epstein-Barr Virus. -- Subject Index.
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|a Sect. 1. The introductory chapters -- Genetic events in cancer delelopment -- Proliferation control pathways -- Tumour suppressor genes -- Cell cycle control -- Apoptosis -- DNA repair -- Angiogenesis and metastasis -- The multistep nature of cancer -- Gene therapy for cancer -- Sect. 2. Tables -- Oncogenes transduced by retroviruses -- Oncogenes activated by retroviral insertion -- Oncogenes at chromosomal translocations -- Tumour suppressor genes detected in human tumours -- Functions of oncoproteins -- Chromosome locations of human proto-oncogenes and tumour -- suppressor genes -- Sect. 3. The oncogenes -- Sect. 4. Tumour suppressor genes -- Sect. 5. Cyclin-dependent kinase inhibitors -- Sect. 6. DNA tumour viruses.
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| 650 |
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|a Oncogenes.
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| 650 |
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|a Antioncogenes.
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| 650 |
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2 |
|a Genes, Tumor Suppressor.
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| 650 |
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2 |
|a Oncogenes.
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| 650 |
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|a MEDICAL
|x Oncology.
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| 650 |
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7 |
|a HEALTH & FITNESS
|x Diseases
|x Cancer.
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| 650 |
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7 |
|a Antioncogenes.
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| 650 |
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7 |
|a Oncogenes.
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| 650 |
1 |
7 |
|a Oncogenen.
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| 650 |
1 |
7 |
|a Suppressorgenen.
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| 952 |
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