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02942nam a2200241 a 4500 |
| 001 |
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20171111234621.0 |
| 008 |
100714s2011 nyua sb 001 0 eng d |
| 020 |
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|z 9780470401965 (cloth)
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| 040 |
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|a CaPaEBR
|z 9780470929261 (e-book)
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| 050 |
1 |
4 |
|a RM301.55
|b .M367 2011eb
|
| 245 |
0 |
0 |
|a Mass spectrometry in drug metabolism and disposition
|b basic principles and applications /
|c edited by Mike S. Lee, Mingshe Zhu.
|
| 260 |
|
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|a Hoboken, N.J. :
|b John Wiley & Sons,
|c c2011.
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| 300 |
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|a xxi, 776 p. :
|b ill.
|
| 490 |
0 |
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|a Wiley series on pharmaceutical science and biotechnology: practices, applications and methods
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| 504 |
|
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|a Includes bibliographical references and index.
|
| 505 |
8 |
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|a (Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition -- The Progression of Drug Metabolism -- Common Biotransformation Reactions -- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry -- Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions -- Experimental Models of Drug Metabolism and Disposition -- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics -- Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes -- Part II Mass Spectrometry in Drug Metabolism: Principles and Common Practice -- Theory and Instrumentation of Mass Spectrometry -- Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification -- Mass Spectral Interpretation -- Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography and Non-Mass Spectrometric Detection -- Part III Applications of New LC/MS Techniques in Drug Metabolism and Disposition -- Quantitative In Vitro ADME Assays using LC-MS as a Part of Early Drug Metabolism Screening -- High Resolution Mass Spectrometry and Drug Metabolite Identification -- Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging -- Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC/MS Platform in Drug Metabolism and Pharmacokinetics Studies -- Quantitative Drug Metabolism with Accelerator Mass Spectrometry -- Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions -- Profiling and Characterization of Herbal Medicine and their Metabolites using LC-MS -- Liquid Chromatography Mass Spectrometry Bioanalysis of Proteins in Biological Matrices -- Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress -- LC-MS in Endogenous Metabolite Profiling and Small Molecule Biomarker Discovery.
|
| 650 |
|
0 |
|a Drugs
|x Metabolism
|x Analysis.
|
| 650 |
|
0 |
|a Metabolites
|x Spectra.
|
| 700 |
1 |
|
|a Lee, Mike S.,
|
| 710 |
2 |
|
|a ebrary, Inc.
|
| 856 |
4 |
0 |
|u http://site.ebrary.com/lib/ucy/Doc?id=10456208
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| 952 |
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|a CY-NiOUC
|b 5a045e586c5ad14ac1edcb95
|c 998a
|d 945l
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|t 1
|x m
|z Books
|
