Table of Contents:
  • 1. Isothermal Titration Calorimetry
  • 2. Direct Optical Detection of Protein-Ligand Interactions
  • 3. Label-Free Detection of Protein-Ligand Interactions by the Quartz Crystal Microbalance
  • 4. Measurement of Solvent Accessibility at protein-protein Interfaces
  • 5. Hydrophobic Interaction Chromatography: Harnessing Multivalent Protein-Surface Interactions for Purification Procedures
  • 6. Sedimentation Velocity Method In the Analytical Ultracentrifuge for the Study of Protein-Protein Interactions
  • 7. Protein Protein-Ligand Interaction Probed by Time-Resolved Crystallography
  • 8. X-Ray Crystallography of protein-ligand Interactions
  • 9. Combined Use of XAFS and Crystallography for studying Protein-Ligand Interactions in Metalloproteins
  • 10. NMR Studies of Protein-Ligand Interactions
  • 11. Probing Heme Protein-Ligand Interactions by UV/Visible Absorption Spectroscopy
  • 12. Ultra fast time-resolved IR studies of Protein-Ligand Interactions
  • 13. Monitoring Protein-Ligand Interactions by Time Resolved FTIR Difference Spectroscopy
  • 14. Proteins in Motion: Resonance Raman Spectroscopy as a probe of functional Intermediates
  • 15. Fluorescence Polarization /Anisotropy Approaches to Study Protein-Ligand Interactions: Effects of errors and Uncertainties
  • 16. Ligand Binding with Stopped-Flow Rapid Mixing
  • 17. Circular Dichroism Spectroscopy for the Study of protein-ligand interactions
  • 18. High- Throughput Screening of Interactions between G Protein-Coupled Receptors and Ligands Using Confocal Optics Microscopy
  • 19. Single-Molecule Study of Protein-Protein and Protein-DNA Interaction Dynamics
  • 20. Application of Fluorescence Correlation Spectroscopy to Hapten-Antibody Binding
  • 21. Atomic Force Microscopy Measurements of Protein-Ligand Interactions on Living Shells
  • 22. Computer Simulation of Protein-Ligand Interactions: Challenges and Applications
  • 23. Force Probe Molecular Dynamics Simulations
  • 24. Study of Ligand-Protein Interactions by Means of Density Functional Theory and First Principles Molecular Dynamics