Cover Image

Matrix metalloproteinases in the central nervous system /

Other Authors: Conant, Katherine.
Format: Book
Language:English
Published: London : Hackensack, NJ : Imperial College Press ; Distributed by World Scientific, ©2005.
Subjects:
Metalloproteinases.
Metalloproteinases > Inhibitors.
Central nervous system.
Extracellular matrix proteins.
Matrix Metalloproteinases > biosynthesis.
Central Nervous System > cytology.
Central Nervous System > physiology.
Matrix Metalloproteinases > physiology.
Tissue Inhibitor of Metalloproteinases > biosynthesis.
Tissue Inhibitor of Metalloproteinases > physiology.
MEDICAL > Neuroscience.
PSYCHOLOGY > Neuropsychology.
Online Access:http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=167338
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050 4 |a QP601.7  |b .M387 2005eb 
245 0 0 |a Matrix metalloproteinases in the central nervous system /  |c editors, Katherine Conant, Paul E. Gottschall. 
260 |a London :  |b Imperial College Press ;  |c ©2005.  |a Hackensack, NJ :  |b Distributed by World Scientific, 
300 |a 1 online resource (vii, 337 pages) :  |b illustrations 
504 |a Includes bibliographical references and index. 
505 0 |a Cover -- Contents -- Foreword -- I.A Brief Overview -- Chapter 1. The Matrix Metalloproteinases and Their Inhibitors Madeleine M. Handsley, Janet Cross, Jelena Gavrilovic, and Dylan R. Edwards -- 1. Introduction -- 2. The MMP Family -- 3. Regulation of MMP Activity -- 4. Endogenous Inhibitors of Metalloproteinases -- 5. Novel Roles for MMPs -- 6. ECM Targets in the CNS -- 7. Generation of Matricryptic Sites in ECM Components -- 8. Growth Factor Liberation from ECM 8220;Stores -- 9. Chemokine Gradient Generation -- 10. Blood-Brain Barrier Substrates for MMPs -- 11. Conclusion -- References -- II. Regulation of MMP Expression -- Chapter 2. Genetic Regulation of the Matrix Metalloproteinases and Related Proteins Tammie Roy and Elizabeth A. Milward -- 1. Introduction -- 2. Stimuli Triggering Alterations in MMP Gene Expression -- 3. Alterations in Other MMPs -- 4. Neurotransmitters -- 5. Cell-Cell and Cell-Matrix Interactions -- 6. Physical and Biochemical Stress -- 7. Suppressive Factors -- 8. Feedback Control -- 9. Signalling Cascades Involved in Regulating MMP Gene Expression -- 10. Genetic Elements Regulating MMP Gene Expression -- 11. Regulation of the MMP-2, MMP-11 and MMP-14 (MT1-MMP) Genes -- 12. Regulation of ADAMs Family Gene Expression -- 13. Regulation of TIMP Gene Expression -- 14. Inverse Regulation of MMPs and TIMPs -- 15. Regulation of TIMPs Independent of MMP Inhibitory Functions -- 16. Post-Transcriptional Regulation of MMP Expression -- 17. Regulation of MMP Gene Expression in the Healthy Nervous System -- 18. Neuronal Expression -- 19. Astrocyte Expression -- 20. Microglial Expression -- 21. Endothelial and Other Cells -- 22. Oligodendrocyte and Schwann Cell Expression -- 23. Expression of TIMPs in the Nervous System -- 24. Expression in Nervous System Development and Plasticity -- 25. MMP Gene Regulation in Nervous System Injury and Disease -- 26. Regulation in Nervous System Malignancies -- 27. Regulation in Nervous System Injury -- 28. Genetic Polymorphisms and MMP Expression -- 29. Conclusion -- References -- Chapter 3. Post-Translational Modification Zezong Gu, Marcus Kaul, and Stuart A. Lipton -- 1. Introduction -- 2. Cysteine Switch Mechanism -- 3. Modification of MMPs by S-Nitrosylation -- 4. S-Nitrosylation Leads to MMP-9 Activation In Vitro -- 5. NO-Induced Subsequent Oxidation -- 6. Peptide Mass Fingerprinting Analysis of Cysteine Residue Post-Translational Modifications -- 7. Structural Model of S-Nitrosylation of MMPs -- 8. MMPs in Neurological Diseases -- 9. Neuronal NOS-Associated Activation of MMP During Stroke -- 10. Exogenous NO-Activated MMP-9 Induces Neuronal Apoptosis in Cerebrocortical Cultures -- 11. MMPs Degrade Extracellular Matrix Components -- 12. Summary -- Acknowledgments -- References -- III. MMP Function -- Chapter 4. Substrates for Metalloendopeptidases in the Central Nervous System Paul E. Gottschall, John D. Sandy, and Dieter R. Zimmermann -- 1. Introduction -- 2. Substrates in the Basal Lamina (Basement Membrane) -- 3. Collagen Type IV -- 4. Laminins -- 5. Perlecan and Other Heparan Sulfate Proteoglycans (HSPG) -- 6. Entactins (Nidogens) -- 7. Substrates in the Neuropil and Perineuronal Nets -- 8. Proteoglycans -- 9. Hyalectans (Lecticans, Aggregating PGs) -- 10. Expression, Localisation and Molecular/Cellular Interactions -- 11. Proteolytic Pr. 
650 0 |a Metalloproteinases. 
650 0 |a Metalloproteinases  |x Inhibitors. 
650 0 |a Central nervous system. 
650 0 |a Extracellular matrix proteins. 
650 2 |a Matrix Metalloproteinases  |x biosynthesis. 
650 2 |a Central Nervous System  |x cytology. 
650 2 |a Central Nervous System  |x physiology. 
650 2 |a Matrix Metalloproteinases  |x physiology. 
650 2 |a Tissue Inhibitor of Metalloproteinases  |x biosynthesis. 
650 2 |a Tissue Inhibitor of Metalloproteinases  |x physiology. 
650 7 |a MEDICAL  |x Neuroscience. 
650 7 |a PSYCHOLOGY  |x Neuropsychology. 
650 7 |a Central nervous system. 
650 7 |a Extracellular matrix proteins. 
650 7 |a Metalloproteinases. 
650 7 |a Metalloproteinases  |x Inhibitors. 
700 1 |a Conant, Katherine. 
856 4 0 |a Gottschall, Paul E.  |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=167338 
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